Bonine, Bonine, Bonine!! Start it the night before and take one each night you are on the ship. Works great with no drowsiness at all. Also, don't know if it was mentioned here or not, but you feel very little movement if any at all while on the ship. If you do, it's a soothing feeling like rocking in a rocking chair. Forget about it and go have a wonderful time, The only problem you will experience is addiction - to cruising, that is!!